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Drug intelligence / Profile preview
[68Ga]Ga-SB03045
- Development stage
- Preclinical
- Lead developer
- BC Cancer
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
[68Ga]Ga-SB03045 is a gallium-68 labeled radiopharmaceutical developed by BC Cancer and the University of British Columbia for positron emission tomography (PET) imaging of fibroblast activation protein (FAP)-expressing tumors. It features a (2S,4S)-4-fluoropyrrolidine-2-carbonitrile pharmacophore conjugated to a DOTA chelator, which binds to FAP with high affinity. In preclinical studies, [68Ga]Ga-SB03045 demonstrated high tumor uptake and favorable tumor-to-background contrast in HEK293T:hFAP tumor xenograft models, comparable to the clinically validated [68Ga]Ga-FAPI-04, making it a promising diagnostic agent for FAP-overexpressing cancers.
- Other names
- [68Ga]-SB03045[68Ga]Ga-sb03045Ga-SB03045Ga-SB-03045Ga-SB 03045natGa-SB03045natGa-SB-03045natGa-SB 03045
02
Targets
FAP (Fibroblast activation protein alpha)
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